Reynolds Center

The Donald W. Reynolds Cardiovascular Clinical Research Center at Stanford closed on June 30th 2006. For information regarding the Center's projects and continuing collaborative opportunities please contact Dr. Mark Hlatky (mah@stanford.edu) or Dr. Tom Quertermous (tomq1@stanford.edu).

The aim of the Donald W. Reynolds Cardiovascular Clinical Research Center at Stanford University is to provide better care for patients with heart disease through the application of modern genetic approaches. As such, projects will utilize modern molecular biology techniques to identify genes associated with heart disease from samples of diseased cells and tissue. These genes will then be examined for unique mutations that can serve as markers to track disease in larger populations.

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The clinical components are designed to address two of the most important issues in cardiovascular medicine today: How do we effectively detect vascular disease in patients without symptoms; and, once patients display symptoms, How do we effectively assess their risk for subsequent complications?

The first approach will specifically examine a group of individuals who suffer from accelerated coronary vascular disease, as evidenced by heart attack at an early age. A control group of older individuals with no evidence of heart disease will be assembled for comparison. In a second separate study, patients will be recruited with the goal of defining genes that are associated with the development of acute complications of coronary vascular disease.

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Individuals with new symptoms of coronary artery disease will be followed and those eventually suffering heart attacks will be compared to those who go on event-free. In addition to genetic evaluation, each of these patient populations will undergo histories and physicals, various biochemical analyses, and both imaging and functional studies to characterize the extent and nature of their vascular disease. Using this multifaceted approach, the Investigators at the Reynolds Center at Stanford University hope to provide insight into the basic mechanisms of heart disease and provide molecular clues to the development of the next generation of therapeutic agents.